This video looks at the circadian rhythm of the skin and how chronodisruption affects its functions. It explores the circadian behaviour of the different skin layers and highlights the complexity of the skin, with multiple circadian clocks in its structures. Despite advances, a thorough understanding of the optical properties of skin layers and the impact of skin appendages is still lacking. Disruption of circadian cycles can accelerate skin ageing and aggravate the symptoms of various pathologies.

This video explores the role of circadian rhythm in various skin diseases, such as psoriasis and atopic dermatitis. It discusses how circadian cycles influence the pathogenesis of psoriasis and atopic dermatitis symptoms, such as pruritus and sleep disturbances, due to an imbalance in melatonin levels. Sleep difficulties in patients with these conditions are highlighted, underlining that a better understanding of the circadian rhythms of the skin may improve the treatment of these pathologies.

This video explores MPOX disease, its global outbreak in 2022-2023 and the current status in 2024. It discusses whether MPOX can be considered a sexually transmitted infection (STI) and compares its symptoms with other STIs, focusing on anal/genital ulcers and proctitis. In addition, the clinical management of MPOX, vaccination strategies and limitations of the available vaccine are addressed.

This month, we cover key studies on atopic dermatitis, alopecia areata, and the eye-related side effects of Dupilumab. Highlights include managing ocular risks with Dupilumab, promising long-term results for Ritlecitinib in alopecia areata, and a study on the effectiveness of systemic treatments in children with severe atopic dermatitis.